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Alternatively, a rash may be unrelated to an infectious organism, such as from an underlying medical illness. Medications, chronic medical conditions, and allergic reactions (hives) are among the multiple different causes of rash.

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Diseases of the joints, such as arthritis, can also affect the joints of the ankle and foot, leading to swelling of the involved areas. Treatments for swollen ankles and feet depend on the particular cause, but anti-inflammatory medications are often used to manage the pain associated with strains and sprains.

Another common form of electrotherapy is with the use of TENS Units. These machines use high and low frequency impulses to stimulate nerves and and essentially close "pain gates" along the spinal cord and neck vertabrae.

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