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An increase in appetite can be a normal physiological response that occurs, for example, in children and adolescents during periods of growth or following strenuous activity or excessive caloric demand. In some case, an increase in appetite can be a sign of an abnormal condition, such as some endocrinologic conditions.

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Cyanosis can also appear at any time later in life and often accompanies conditions in which lung function is compromised or conditions in which the hearts pumping function is compromised. The presence of abnormal forms of hemoglobin or other abnormalities of the blood cells can also sometimes cause cyanosis.

Insomnia is the perception of inadequate or poor-quality sleep. It can be due to problems falling asleep, early wakening, waking frequently during the night, unrefreshing sleep, or a combination of these. Contrary to some popular beliefs, insomnia is not defined by the total amount of sleep one gets or how long it takes a person to fall asleep. Individuals can vary in their need for sleep, and in the time required to fall asleep.

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